Inducing Na+ Site Rearrangement Through a Cosubstitution Strategy for Rapid Na Diffusion Kinetics of P2-Type Layered Metal Oxides.

The P2-layered metal oxide cathode materials are crucial for constructing high-rate sodium-ion batteries (SIBs); however, its practical application is hindered by the high Na+ diffusion barrier resulting from Na+/vacancy ordering. Herein, a Li/Zn cosubstitution P2-Na0.67Ni0.33Mn0.67O2 (NLNZM) cathode was synthesized via a sol-gel method assisted with citric acid, which can induce the rearrangement of Na+ sites to disrupt ordered structures. The XRD Rietveld refinement confirms a higher occupancy of Na+ at Nae sites with low diffusion barriers through the Li/Zn cosubstitution. In addition, the highly reversible phase evolution of the NLNZM is confirmed through in situ XRD results, thereby ensuring the stability of the structure with low volume change rate (0.78%). Furthermore, Li and Zn can reduce the surface energy and increase the interlayered distance to achieve rapid interfacial kinetics. As a result, the NLNZM has exhibited a high reversible capacity of 152.8 mAh g-1 and an outstanding rate performance of 103.4 mAh g-1 at 5C. After 200 cycles at 5C, the capacity retention rate is 81.1%. This work proposes a cosubstitution strategy to induce Na+/vacancy disorder for achieving rapid Na+ migration as a cathode material for SIBs.

Tunable Adhesion for All-Dry Transfer of 2D Materials Enabled by the Freezing of Transfer Medium.

The real applications of chemical vapor deposition (CVD)-grown graphene films require the reliable techniques for transferring graphene from growth substrates onto application-specific substrates. The transfer approaches that avoid the use of organic solvents, etchants, and strong bases are compatible with industrial batch processing, in which graphene transfer should be conducted by dry exfoliation and lamination. However, all-dry transfer of graphene remains unachievable owing to the difficulty in precisely controlling interfacial adhesion to enable the crack- and contamination-free transfer. Herein, through controllable crosslinking of transfer medium polymer, the adhesion is successfully tuned between the polymer and graphene for all-dry transfer of graphene wafers. Stronger adhesion enables crack-free peeling of the graphene from growth substrates, while reduced adhesion facilitates the exfoliation of polymer from graphene surface leaving an ultraclean surface. This work provides an industrially compatible approach for transferring 2D materials, key for their future applications, and offers a route for tuning the interfacial adhesion that would allow for the transfer-enabled fabrication of van der Waals heterostructures.

Surface reconstruction in amorphous CoFe-based hydroxides/crystalline phosphide heterostructure for accelerated saline water electrolysis.

Developing electrocatalysts with high activity and robust performance for large-scale seawater electrolysis to produce hydrogen holds immense significance. Herein, a highly active bifunctional electrode composed of amorphous cobalt-iron layered double hydroxides (CoFeLDH) and crystalline nickel phosphide (Ni2P) (denoted as CoFeLDH@Ni2P), is employed to boost hydrogen production through seawater electrolysis. The strong interface coupling effectively modifies the electronic structure at active sites, thereby accelerating the catalytic reaction kinetics. Impressively, in situ Raman and post-stability analyses demonstrate a unique reconstruction behavior on the CoFeLDH@Ni2P electrode. Bimetal co-incorporated NiOOH (CoFe-NiOOH) and Ni(OH)2 species are formed during the oxygen evolution reaction (OER), while CoFeLDH@Ni2P can transform into Ni(OH)2 species during the hydrogen evolution reaction (HER) process. Furthermore, the highly negatively charged surface selectively rejects Cl- ions by formed PO43-, endowing CoFeLDH@Ni2P with excellent tolerance and promising durability in saline electrolytes. Consequently, the CoFeLDH@Ni2P electrode exhibits an overpotential of 106 mV for HER at 10 mA cm-2 and 308 mV for OER to achieve 100 mA cm-2 in 1.0 M KOH solution. Additionally, the CoFeLDH@Ni2P(+,-) electrolyzer requires a low cell voltage of 1.56 V to deliver 10 mA cm-2 in 1.0 M KOH + Seasalt. This work presents an appealing strategy for the rational design of advanced electrocatalysts with amorphous-crystalline interfaces, which reveals the source of the activity of transition-metal phosphating compounds in saline water electrolysis.

Visible-Light-Driven NO Release from Postmodified MOFs via Photoinduced Electron Transfer for Antibacterial Application.

Photoresponsive nitric oxide (NO)-releasing materials (NORMs) enable the spatiotemporal delivery of NO to facilitate their potential applications in physiological conditions. Here two novel metal-organic frameworks (MOFs)-based photoactive NORMs achieved by the incorporation of prefunctionalized NO donors into the photosensitive Fe-MOFs via a postmodification strategy is reported. The modified Fe-MOFs display superior photoactivity of NO release when exposed to visible light (up to 720 nm). Significantly, the visible-light-driven NO release properties are further corroborated by their efficient antibacterial performance.

Role of dietary tea polyphenols on growth performance and gut health benefits in juvenile hybrid sturgeon (Acipenser baerii ♀ × A. schrenckii ♂).

The present study aimed to evaluate the effects of dietary TPs on growth performance, intestinal digestion, microflora and immunity in juvenile hybrid sturgeon. A total of 450 fish (97.20 ± 0.18 g) were randomly divided into a standard diet (TP-0) or four treatments consisting of a standard diet supplemented with four concentrations of TPs (mg/kg): 100 (TP-100), 300 (TP-300), 500 (TP-500), and 1000 (TP-1000) for 56 days. The TP-300 significantly increased weight gain rate (WGR) and specific growth rate (SGR) (p < 0.05), and TP-1000 significantly increased the feed conversion ratio (FCR) (p < 0.05). TP-300 and TP-500 significantly increased intestinal trypsin, amylase, and lipase activities (p < 0.05). Besides, TP-300 significantly enhanced total antioxidant capacity (T-AOC) and the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) and decreased malondialdehyde (MDA) content (p < 0.05). Moreover, TP-300 decreased the expression levels of tumor necrosis factor-alpha (TNF-α), interleukin 8 (IL-8), and interleukin 1ß(IL-1ß) compared with TP-0 and TP-1000 (p < 0.05). In addition, the intestinal microbiota diversity in the TP-300 group was observably higher, the dominant microbiota was Bacteroidota, Cyanobacteria, Proteobacteria and Firmicutes at the phylum level, Enterobacteriaceae, Nostocaceae and Clostridiaceae at the family level. The relative abundances of potential probiotics including Rhodobacteraceae and potential pathogens especially Clostridiaceae were the highest, and lowest, respectively. In conclusion, TP-300 altered the abundance of microbial taxa, resulting in enhancing the intestinal digestion, antioxidant status and non-specific immunity to improve the growth performance in juvenile hybrid sturgeon.

A New Analytical Large-Signal Model for Quasi-Ballistic Transport in InGaAs HEMTs Accommodating Dislocation Scattering.

A surface-potential-based analytical large-signal model, which is applicable to both ballistic and quasi-ballistic transport in InGaAs high electron mobility transistors, is developed. Based on the one-flux method and a new transmission coefficient, a new two-dimensional electron gas charge density is derived, while the dislocation scattering is novelly taken into account. Then, a unified expression for Ef valid in all the regions of gate voltages is determined, which is utilized to directly calculate the surface potential. The flux is used to derive the drain current model incorporating important physical effects. Moreover, the gate-source capacitance Cgs and gate-drain capacitance Cgd are obtained analytically. The model is extensively validated with the numerical simulations and measured data of the InGaAs HEMT device with the gate length of 100 nm. The model is in excellent agreement with the measurements under I-V, C-V, small-signal conditions, and large-signal conditions.

A Review of In-Situ Techniques for Probing Active Sites and Mechanisms of Electrocatalytic Oxygen Reduction Reactions.

Electrocatalytic oxygen reduction reaction (ORR) is one of the most important reactions in electrochemical energy technologies such as fuel cells and metal-O2/air batteries, etc. However, the essential catalysts to overcome its slow reaction kinetic always undergo a complex dynamic evolution in the actual catalytic process, and the concomitant intermediates and catalytic products also occur continuous conversion and reconstruction. This makes them difficult to be accurately captured, making the identification of ORR active sites and the elucidation of ORR mechanisms difficult. Thus, it is necessary to use extensive in-situ characterization techniques to proceed the real-time monitoring of the catalyst structure and the evolution state of intermediates and products during ORR. This work reviews the major advances in the use of various in-situ techniques to characterize the catalytic processes of various catalysts. Specifically, the catalyst structure evolutions revealed directly by in-situ techniques are systematically summarized, such as phase, valence, electronic transfer, coordination, and spin states varies. In-situ revelation of intermediate adsorption/desorption behavior, and the real-time monitoring of the product nucleation, growth, and reconstruction evolution are equally emphasized in the discussion. Other interference factors, as well as in-situ signal assignment with the aid of theoretical calculations, are also covered. Finally, some major challenges and prospects of in-situ techniques for future catalysts research in the ORR process are proposed.

Stress responses of the intestinal digestion, antioxidant status, microbiota and non-specific immunity in Songpu mirror carp (Cyprinus carpio L.) under starvation.

Songpu mirror carp, Cyprinus carpio L., is a new variety of common carp that has become an economically important freshwater fish in China. However, it remains unknown how its metabolism is regulated under starvation. Here, we investigated how intestinal digestion, antioxidant status, microbiota and immune activities were affected under starvation stress. The feeding regimes were designed as follows: ST0 comprised fish allowed to feed continuously; ST1 comprised fish starved for 1 week; ST2 comprised fish starved for 2 weeks; ST3 comprised fish starved for 3 weeks; ST4 comprised fish starved for 4 weeks. Our results showed a significant decrease in the level of intestinal amylase, lipase, and protease activities in the group ST4 (P < 0.05). Compared with the control group, intestinal antioxidant enzyme activities were significantly increased during short-term starvation. The gene expression levels of interleukin 1ß (IL-1ß), interleukin 8 (IL-8) and tumor necrosis factor-alpha (TNF-α) were elevated in the groups ST3 and ST4. We also detected the reduction in the expression levels of interleukin 10 (IL-10) and transforming growth factor ß (TGF-ß2) compared with those of the group ST0. Notably, the gut microbial composition was dominated by Proteobacteria, Acidobacteria, Actinobacteria, Bacteroidetes, and Firmicutes. The relative abundance of the dominant microbial phyla changed significantly under starvation stress. Taken together, our results suggest that starvation can induce the change of intestinal digestion, non-specific immunity and microbiota in Songpu mirror carp, and provide new insights into its habitat selection and adaptation to environmental changes.

Comparing the efficacy and safety of the Skyflow device with those of the Solitaire FR stent in patients with acute ischemic stroke: a prospective, multicenter, randomized, non-inferiority clinical trial.

BACKGROUND: Mechanical thrombectomy is the standard treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO) in the anterior circulation. This trial aimed to indicate whether Skyflow, a new thrombectomy device, could achieve the same safety and efficacy as Solitaire FR in the treatment of AIS. METHODS: This study was a prospective, multicenter, randomized, single blind, parallel, positive controlled, non-inferiority clinical trial. Patients with intracranial anterior circulation LVO within 8 hours from onset were included to receive thrombectomy treatment with either the Skyflow or Solitaire FR stent retriever. The primary endpoint was the rate of successful reperfusion (modified Treatment In Cerebral Infarction (mTICI) ≥2b) after the operation. The safety endpoints were the rate of symptomatic intracranial hemorrhage (sICH) and subarachnoid hemorrhage (SAH) at 24 hours after operation. RESULTS: A total of 95 and 97 patients were involved in the Skyflow group and Solitaire FR group, respectively. A successful reperfusion (mTICI ≥2b) was finally achieved in 84 (88.4%) patients in the Skyflow group and 80 (82.5%) patients in the Solitaire FR group. Skyflow was non-inferior to Solitaire FR in regard to the primary outcome, with the criterion of a non-inferiority margin of 12.5% (p=0.0002) after being adjusted for the combined center effect and the National Institutes of Health Stroke Scale (NIHSS) score. The rate of periprocedural sICH and SAH did not differ significantly between the two groups. CONCLUSION: Endovascular thrombectomy with the Skyflow stent retriever was non-inferior to Solitaire FR with regard to successful reperfusion in AIS due to LVO (with a pre-specified non-inferiority margin of 12.5%).

Hollow heterostructure design enables self-cleaning surface for enhanced polysulfides conversion in advanced lithium-sulfur batteries.

Constructing interpenetrating heterointerface with reasonable interface energy barriers to improve electron/ion transport and accelerate the deposition/decomposition of lithium sulfide (Li2S) is an effective method to improve the electrochemical performance of lithium-sulfur (Li-S) batteries. Herein, NiCoO2/NiCoP heterostructures with hollow nanocage morphology are prepared for efficient multifunctional Li-S batteries. The hollow nanocage structure exposes abundant active sites, traps lithium polysulfides and inhibits the shuttle effect. The NiCoO2/NiCoP heterostructure, combing strong adsorption capacity of NiCoO2 and excellent catalytic ability of NiCoP, facilitates the process of anchoring-diffusion-transformation of polysulfides. The successful construction of heterostructures reduces the reaction barrier, accelerating the lithium ion (Li+) diffusion rate and thus effectively enhancing the redox reaction kinetics. More importantly, NiCoO2/NiCoP heterostructure plays a role in self-cleaning that minimizes solid sulfur species accumulation to maintain surface clean during long cycling for a continuously catalysis of the polysulfides conversion reactions. With the merit of these features, the NiCoO2/NiCoP modified separator exhibits excellent cycling stability with a low capacity decay of 0.043% per cycle up to 1000 cycles at 2 C. The design of NiCoO2/NiCoP hollow nanocage heterostructures offers a new option for high-performance electrochemical energy storage devices.

Understanding the modulation effect and surface chemistry in a heteroatom incorporated graphene-like matrix toward high-rate lithium-sulfur batteries.

The underlying interface effects of sulfur hosts/polysulfides at the molecular level are of great significance to achieve advanced lithium-sulfur batteries. Herein, we systematically study the polysulfide-binding ability and the decomposition energy barrier of Li2S enabled by different kinds of nitrogen (pyridinic N, pyrrolic N and graphitic N) and phosphorus (P-O, PO and graphitic P) doping and decipher their inherent modulation effect. The doping process helps in forming a graphene-like structure and increases the micropores/mesopores, which can expose more active sites to come into contact with polysulfides. First-principles calculations reveal that the PO possesses the highest binding energies with polysulfides due to the weakening of the chemical bonds. Besides, PO as a promoter is beneficial for the free diffusion of lithium ions, and the pyridinic N and pyrrolic N can greatly reduce the kinetic barrier and catalyze the polysulfide conversion. The synergetic effects of nitrogen and phosphorus as bifunctional active centers help in achieving an in situ adsorption-diffusion-conversion process of polysulfides. Benefiting from these features, the graphene-like network achieves superior rate capability (a high reversible capacity of 954 mA h g-1 at 2C) and long-term stability (an ultralow degradation rate of 0.009% around 800 cycles at 5C). Even at a high sulfur loading of 5.6 mg cm-2, the cell can deliver an areal capacity of 4.6 mA h cm-2 at 0.2C.

A high-performance asymmetric supercapacitor-based (CuCo)Se2/GA cathode and FeSe2/GA anode with enhanced kinetics matching.

The performance of asymmetric supercapacitors (ASCs) is limited by the poorly matched electrochemical kinetics of available electrode materials, which generally results in reduced energy density and inadequate voltage utilization. Herein, a porous conductive graphene aerogel (GA) scaffold was decorated with copper cobalt selenide ((CuCo)Se2) or iron selenide (FeSe2) to construct positive and negative electrodes, respectively. The (CuCo)Se2/GA and FeSe2/GA electrodes exhibited high specific capacitances of 672 and 940 F g-1, respectively, at 1 A g-1. The capacitance contributions from the Co3+/Co2+ and Fe3+/Fe2+ redox couple for the positive and negative electrodes were determined to elucidate the energy storage mechanism. Furthermore, the kinetics study of the two electrodes was performed, revealing b values ranging between 0.7 and 1 at various scan rates and demonstrating that the surface-controlled processes played the dominant role, leading to fast charge storage capability for both electrodes. Fabrication of an ASC device with a configuration of (CuCo)Se2/GA//FeSe2/GA resulted in a voltage of 1.6 V, a high energy density of 39 W h kg-1, and a power density of 702 W kg-1. The excellent electrochemical performances of the (CuCo)Se2/GA and FeSe2/GA electrodes demonstrate their potential applications in energy storage devices.

Cytotoxic effects, inflammatory response and apoptosis induction of cyclophosphamide in the peripheral blood leukocyte of blunt snout bream (Megalobrama amblycephala).

The present study was aimed to evaluate the effects of the cyclophosphamide (CY) exposure (Control, 0.032, 0.32, 1.0, 1.6 and 3.2 mg/mL) on the damage in the peripheral blood leukocytes of blunt snout bream for 24 h, which including cell viability, apoptosis, lactate dehydrogenase (LDH) release, mitochondrial membrane potential (Δѱm), ROS, antioxidant enzyme activity and the relative mRNA levels of apoptosis. Results showed that cell viability and Δѱm effects of CY were greatly reduced, and occurred in a dose-dependent manner. CY exposure (0.32-3.2 mg/mL) significantly increased the LDH release and induced apoptosis accompanied by ΔΨm disruption and ROS generation compared to the control. The cellular ROS was significantly increased with increase of CY level from 0.032 mg/mL to 1 mg/mL and the plateau occurred at 0.32 mg/mL. Additionally CY exposure led to oxidative stress as evidenced by significantly the decrease of SOD and CAT and increase of MDA concentration after treating cells with 3.2 mg/mL of CY. Besides, the relative mRNA levels of caspase-3 in the dose of 0.032, 0.32 mg/mL CY, caspase-9 and interleukins-1ß (IL-1ß) in the dose of 0.32 mg/mL CY, tumor necrosis factor-alpha (TNF-α) in the dose of 0.032 mg/mL CY significantly higher than that of the control. In conclusion, 0.32-3.2 mg/mL CY could lead to cytotoxic effect, inflammatory response and induce the apoptosis of the peripheral blood leukocyte of Megalobrama amblycephala.

Novel binuclear and trinuclear metal (II) complexes: DNA interactions and in vitro anticancer activity through apoptosis.

A water soluble trinuclear copper(II) complex and a binuclear cobalt(II) complex, namely Cu3(ppbm)2(SO4)3 (1) and Co2(ppbm)2(NO3)4 (2) (ppbm = 2-(pyridin-2-yl)-1-(pyridin-3-ylmethyl)- 1H-benzo[d]imidazole), have been successfully synthesized and characterized by elemental analysis, IR Spectroscopy, electrospray ionization mass spectra (ESI-MS). The interaction of the new complexes with DNA has been explored using spectroscopy methods, indicating that the complexes 1 and 2 bind to DNA via noncovalent interactions. DNA cleavage experiment suggested that the complex 1 exhibits efficient DNA cleavage activities in the presence of ascorbate (Asc), hydrogen peroxide may serve as the major cleavage active species. The cytotoxicity assay showed that complex 1 exhibited significant inhibitory activity toward the proliferation of several tumor cell lines, with a lower IC50 value than cisplatin and complex 2, indicating that it had the potential to act as effective anticancer agent. The morphological staining assays showed that 1 apparently induced the TFK-1 cells apoptosis. Besides, cellular uptake experiment on TFK-1 cells revealed that complex 1 accumulates primarily inside the nucleus. The apoptosis was attributable to the metal-assisted generation of reactive oxygen species (ROS).

The effects of emodin on cell viability, respiratory burst and gene expression of Nrf2-Keap1 signaling molecules in the peripheral blood leukocytes of blunt snout bream (Megalobrama amblycephala).

We determined the effects of emodin on the cell viability, respiratory burst activity, mRNA levels of antioxidative enzymes (Cu-Zn SOD, CAT and NOX2), and gene expressions of the Nrf2-Keap1 signaling molecules in the peripheral blood leukocytes of blunt snout bream. Triplicate groups of cultured cells were treated with different concentrations of emodin (0.04-25 µg/ml) for 24 h. Results showed that the emodin caused a dramatic loss in cell viability, and occurred in a dose-dependent manner. Emodin exposure (1-25 µg/ml) were significantly induced the ROS generation compared to the control. The respiratory burst and NADPH oxidase activities were significantly induced at a concentration of 0.20 µg/ml, and inhibited at 25 µg/ml. Besides, mRNA levels of antioxidant enzyme genes were dramatically regulated by emodin exposure for 24 h. During low concentrations of exposure, mRNA levels of Cu-Zn SOD in the cells treated with 0.04, 0.20 µg/ml, CAT, NOX2 and Nrf2 in the cells treated with 1 µg/ml were sharply increased, respectively. Whereas, high concentrations were dramatically down-regulated the gene expressions of CAT in the cells treated with 5, 25 µg/ml and NOX2 in the cells treated with 25 µg/ml. Furthermore, sharp increase in Keap1and Bach1 expression levels were observed a dose-dependent manner. In conclusion, this study demonstrated that emodin could induce antioxidant defenses which were involved in cytotoxic activities, respiratory burst and the transcriptional regulation levels of antioxidant enzymes and Nrf2-Keap1 signaling molecules.

Comparative proteomic analysis of liver antioxidant mechanisms in Megalobrama amblycephala stimulated with dietary emodin.

Oxidative stress is a toxicological endpoint that correlates with the nutrition status of fish through cellular damage, inflammation, and apoptosis. In order to understand the antioxidant mechanism induced by dietary emodin in Megalobrama amblycephala liver, a comparative proteomic analysis was performed to investigate the proteome alteration under emodin administration. 27 altered protein spots were separated under 30 mg kg-1 emodin stimulation based on 2-DE, and were all successfully identified using MALDI-TOF/TOF, representing 17 unique proteins. These proteins were functionally classified into antioxidant, metabolism, cytoskeleton, chaperone, signal transduction and cofactor groups. Network interaction and Gene Ontology annotation indicated 10 unique proteins were closely related to antioxidation and directly regulated by each other. Compared with the control group, administration of 30 mg kg-1 emodin significantly increased the antioxidant-related mRNA expressions of GPx1, GSTm and HSP70, but decreased the mRNA expressions of GAPDH and Sord, which was consistent with the protein expression. Nevertheless, Pgk1 and Aldh8a1 were up- and down-regulated, and ALDOB was down- and up-regulated at the mRNA and protein levels, respectively. These results revealed that the altered proteins enhanced antioxidation via complex regulatory mechanisms, and 30 mg kg-1 emodin was a suitable immunostimulant for M. amblycephala.

3D Image-Guided Percutaneous Radiofrequency Thermocoagulation of the Maxillary Branch of the Trigeminal Nerve Through Foramen Rotundum for the Treatment of Trigeminal Neuralgia.

Percutaneous radiofrequency thermocoagulation of the trigeminal ganglion through the foramen ovale is a well-established procedure for the treatment of trigeminal neuralgia (TN). However, this approach can be tricky when individual trigeminal sub-branch nerve block is required. We report our initial experience of image-guided radiofrequency thermocoagulation of the maxillary branch through the use of foramen rotundum.From February 2012 to February 2015, we treated 25 patients with isolated TN of the maxillary branch. Radiofrequency thermocoagulation of the maxillary branch through the foramen rotundum was performed under fluoroscopy. TN pain was evaluated using the visual analogue scale both before and after the procedure.The mean preoperative visual analogue scale score was 8.6 ±â€Š0.8. The pain completely disappeared after the initial procedure in 22 patients and after a second procedure in 2 patients. An additional patient had a postoperative visual analogue scale score of 2 and did not undergo further treatment. Facial numbness occurred in 23 patients but was tolerable. Patients were followed up for a mean of 14.74 months (range, 1-29 months). Recurrence was observed in 9 patients (36%) during the follow-up period. All recurrences were well managed with repeat procedures.Percutaneous radiofrequency thermocoagulation of the maxillary branch through the foramen rotundum under fluoroscopy is a safe and effective procedure for the treatment of isolated TN of the maxillary branch.

N'-(Butan-2-yl-idene)furan-2-carbohydrazide.

The title Schiff base compound, C(9)H(12)N(2)O(2), was obtained from a condensation reaction of butan-2-one and furan-2-carbohydrazide. The furan ring and the hydrazide fragment are roughly planar, the largest deviation from the mean plane being 0.069 (2)Å, but the butanyl-idene group is twisted slightly with respect to this plane by a dihedral angle of 5.2 (3)°. In the crystal, inter-molecular N-H⋯O hydrogen bonds link pairs of inversion-related mol-ecules, forming dimers of R(2) (2)(8) graph-set motif.

Methyl 2-meth-oxy-4-{[2-(4-nitro-phen-yl)hydrazinyl-idene]meth-yl}benzoate.

The mol-ecule of the title Schiff base compound, C(16)H(15)N(3)O(5), obtained from a condensation reaction of 4-acet-oxy-3-meth-oxy-benzaldehyde and 4-nitro-phenyl-hydrazine, adopts an E geometry with respect to the C=N double bond. The mol-ecule is roughly planar, with the two benzene rings twisted slightly with respect to each other by a dihedral angle of 6.90 (9)°. In the crystal, inter-molecular N-H⋯O hydrogen bonds link centrosymmetrically related pairs of mol-ecules, forming dimers of R(2) (2)(22) graph-set motif. The dimers are further connected through slipped π-π inter-actions between symmetry-related benzene rings [centroid-centroid distance of 3.646 (1) Å, offset angle of 15.4°].